Dr Niantao Deng
Garvan Institute of Medical Research
Understanding breast cancer patients’ response to neoadjuvant chemotherapy at single-cell
Chemotherapy prior to surgery is used with the intention of rendering large tumours operable in locally advanced breast cancer and has become increasingly common. Treatment responses can then be assessed in realtime, and tissue samples can be collected throughout the course of treatment. In this study, we would like to understand the mechanisms of resistance by comparing samples of responders and non-responders before and after chemotherapy at the single-cell level.